Chandigarh: In what comes as a ray of hope for cancer sufferers, PGI administration is actively working in direction of establishing a Good Manufacturing Follow (GMP) laboratory to advance its capabilities in stem cell and gene therapies. The initiative goals at enhancing the establishment’s capability for chopping-edge medical remedies.
Within the absence of such a GMP, the institute can not carry out cell therapies, gene enhancing, stem cell remedy, and even CAR T (immunotherapy in which a affected person’s personal T cells are genetically modified in a lab to recognise and assault cancer cells, then infused again into the physique to struggle the cancer).
PGI at the moment utilises exterior laboratories in Bengaluru and Mumbai for CAR T-cell remedy. Institution of a GMP laboratory would permit PGI to offer CAR T-cell remedy on-site, doubtlessly growing accessibility for sufferers. Prof Pankaj Malhotra, head of the division of scientific haematology and medical oncology, PGI, mentioned, “Having our personal GMP laboratory would offer self-reliance and the flexibility to offer these therapies to needy sufferers for free.” He added, “We now have handled some eight sufferers up to now and it’s expensive. With our personal set-up, we will be self-reliant and assist poor sufferers.”Growth of a GMP laboratory is essential for PGI to fulfill present regulatory requirements for stem cell and gene remedy procedures. This facility will allow the institute to conduct such advanced therapies in-house, decreasing reliance on exterior laboratories. PGI is reportedly collaborating with Tata Memorial Hospital, Mumbai, to facilitate the institution of the GMP laboratory.
Dr Gaurav Narula, a paediatric haematologist-oncologist at TMH, who performed a key function in creating India’s first CAR-T cell remedy, was in PGI on Tuesday throughout the nationwide convention on present developments in translational analysis organised by the division of translational and regenerative medication, PGI. “We’re increasing our analysis into different functions of CAR T-cell remedy, together with viral infections after transplant surgical procedure in immunosuppressed sufferers. Whereas the remedy at the moment targets haematological cancers, its potential is huge,” mentioned Dr Narula. His group shall information PGI in creating the GMP laboratory set-up, which might value over Rs 20 crore.
BOX: Work halted just a few years in the past
Work on stem cell in PGI for kidney transplant, which began just a few years in the past got here, to a standstill as a result of new requirements for GMP laboratory. Researchers labored on mesenchymal stem cells for kidney transplant, the place these cells have been faraway from sufferers 4 weeks earlier than the surgical procedure. MSCs are a sort of stem cell discovered in numerous tissues, together with bone marrow, which have the flexibility to distinguish into completely different cell varieties and play a task in tissue restore and regeneration.
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